| AFC Bournemouth | 5 | - | 0 | Milton Keynes Dons |
| Barrow | 1 | - | 0 | Scunthorpe United |
| Birmingham City | 1 | - | 0 | Colchester United |
| Blackburn Rovers | 1 | - | 2 | Morecambe |
| Blackpool | 3 | - | 0 | Middlesbrough |
| Bolton Wanderers (pens 5-4) | 0 | - | 0 | Barnsley |
| Bristol Rovers | 0 | - | 2 | Cheltenham Town |
| Burton Albion | 1 | - | 1 | Oxford United (pens 2-4) |
| Cambridge United (pens 3-1) | 0 | - | 0 | Swindon Town |
| Cardiff City | 3 | - | 2 | Sutton United |
| Charlton Athletic | 0 | - | 1 | AFC Wimbledon |
| Coventry City | 1 | - | 2 | Northampton Town |
| Crawley Town | 2 | - | 2 | Gillingham (pens 9-10) |
| Derby County (pens 5-3) | 3 | - | 3 | Salford City |
| Exeter City | 0 | - | 0 | Wycombe Wanderers (pens 3-4) |
| Forest Green Rovers (pens 6-5) | 2 | - | 2 | Bristol City |
| Harrogate Town | | - | | Rochdale (W/O) |
| Hartlepool United | 0 | - | 1 | Crewe Alexandra |
| Hull City | 1 | - | 1 | Wigan Athletic (pens 7-8) |
| Ipswich Town | 0 | - | 1 | Newport County |
| Leyton Orient | 1 | - | 1 | Queens Park Rangers (pens 3-5) |
| Mansfield Town | 0 | - | 3 | Preston North End |
| Millwall | 2 | - | 1 | Portsmouth |
| Nottingham Forest | 2 | - | 1 | Bradford City |
| Oldham Athletic (pens 4-3) | 2 | - | 2 | Tranmere Rovers |
| Peterborough United | 0 | - | 4 | Plymouth Argyle |
| Port Vale | 1 | - | 2 | Sunderland |
| Reading | 0 | - | 3 | Swansea City |
| Rotherham United | 1 | - | 2 | Accrington Stanley |
| Sheffield United | 1 | - | 0 | Carlisle United |
| Sheffield Wednesday | 0 | - | 0 | Huddersfield Town (pens 2-4) |
| Shrewsbury Town (pens 4-2) | 2 | - | 2 | Lincoln City |
| Stevenage (pens 3-0) | 2 | - | 2 | Luton Town |
| Stoke City | 2 | - | 1 | Fleetwood Town |
| Walsall | 0 | - | 0 | Doncaster Rovers (pens 3-4) |
| | | | |
| Football League (EFL) Cup Second Round | Football League (EFL) Cup Second Round | Football League (EFL) Cup Second Round | Football League (EFL) Cup Second Round | Football League (EFL) Cup Second Round |
| Barrow | 0 | - | 6 | Aston Villa |
| Birmingham City | 0 | - | 2 | Fulham |
| Blackpool | 2 | - | 3 | Sunderland |
| Brentford | 3 | - | 1 | Forest Green Rovers |
| Cardiff City | 0 | - | 2 | Brighton & Hove Albion |
| Gillingham | 1 | - | 1 | Cheltenham Town (pens 4-5) |
| Huddersfield Town | 1 | - | 2 | Everton |
| Leeds United | 3 | - | 0 | Crewe Alexandra |
| Millwall | 3 | - | 1 | Cambridge United |
| Morecambe | 2 | - | 4 | Preston North End |
| Newcastle United | 0 | - | 0 | Burnley (pens 3-4) |
| Newport County | 0 | - | 8 | Southampton |
| Northampton Town | 0 | - | 1 | AFC Wimbledon |
| Norwich City | 6 | - | 0 | AFC Bournemouth |
| Nottingham Forest | 0 | - | 4 | Wolverhampton Wanderers |
| Oldham Athletic (pens 5-4) | 0 | - | 0 | Accrington Stanley |
| Queens Park Rangers | 2 | - | 0 | Oxford United |
| Sheffield United | 2 | - | 1 | Derby County |
| Shrewsbury Town | 0 | - | 2 | Rochdale |
| Stevenage | 2 | - | 2 | Wycombe Wanderers (pens 3-5) |
| Stoke City | 2 | - | 0 | Doncaster Rovers |
| Swansea City | 4 | - | 1 | Plymouth Argyle |
| Watford | 1 | - | 0 | Crystal Palace |
| West Bromwich Albion | 0 | - | 6 | Arsenal |
| Wigan Athletic (pens 5-4) | 0 | - | 0 | Bolton Wanderers |
| | | | |
| Football League (EFL) Cup Third Round | Football League (EFL) Cup Third Round | Football League (EFL) Cup Third Round | Football League (EFL) Cup Third Round | Football League (EFL) Cup Third Round |
| Arsenal | 3 | - | 0 | AFC Wimbledon |
| Brentford | 7 | - | 0 | Oldham Athletic |
| Brighton & Hove Albion | 2 | - | 0 | Swansea City |
| Burnley | 4 | - | 1 | Rochdale |
| Chelsea (pens 4-3) | 1 | - | 1 | Aston Villa |
| Fulham | 0 | - | 0 | Leeds United (pens 6-5) |
| Manchester City | 6 | - | 1 | Wycombe Wanderers |
| Manchester United | 0 | - | 1 | West Ham United |
| Millwall | 0 | - | 2 | Leicester City |
| Norwich City | 0 | - | 3 | Liverpool |
| Preston North End | 4 | - | 1 | Cheltenham Town |
| Queens Park Rangers (pens 8-7) | 2 | - | 2 | Everton |
| Sheffield United | 2 | - | 2 | Southampton (pens 4-2) |
| Watford | 1 | - | 3 | Stoke City |
| Wigan Athletic | 0 | - | 2 | Sunderland |
| Wolverhampton Wanderers | 2 | - | 2 | Tottenham Hotspur (pens 3-2) |
| | | | |
| Football League (EFL) Cup Fourth Round | Football League (EFL) Cup Fourth Round | Football League (EFL) Cup Fourth Round | Football League (EFL) Cup Fourth Round | Football League (EFL) Cup Fourth Round |
| Arsenal | 2 | - | 0 | Leeds United |
| Burnley | 0 | - | 1 | Tottenham Hotspur |
| Chelsea (pens 4-3) | 1 | - | 1 | Southampton |
| Leicester City (pens 4-2) | 2 | - | 2 | Brighton & Hove Albion |
| Preston North End | 0 | - | 2 | Liverpool |
| Queens Park Rangers | 0 | - | 0 | Sunderland (pens 3-1) |
| Stoke City | 1 | - | 2 | Brentford |
| West Ham United (pens 5-3) | 0 | - | 0 | Manchester City |
| | | | |
| Football League (EFL) Cup Fifth Round | Football League (EFL) Cup Fifth Round | Football League (EFL) Cup Fifth Round | Football League (EFL) Cup Fifth Round | Football League (EFL) Cup Fifth Round |
| Arsenal | 5 - 1 | | | Sunderland |
| Brentford | 0 - 2 | | | Chelsea |
| Liverpool (pens 5-4) | 3 - 3 | 22.12.21 | 22.12.21 | Leicester City |
| Tottenham Hotspur | 2 - 1 | 22.12.21 | 22.12.21 | West Ham United |
| | | | |
| Football League (EFL) Cup Semi-Finals 5th & 6th January 2022 | Football League (EFL) Cup Semi-Finals 5th & 6th January 2022 | Football League (EFL) Cup Semi-Finals 5th & 6th January 2022 | Football League (EFL) Cup Semi-Finals 5th & 6th January 2022 | Football League (EFL) Cup Semi-Finals 5th & 6th January 2022 |
| Chelsea | 2 | - | 0 | Tottenham Hotspur |
| Liverpool | 0 | - | 0 | Arsenal |
| Tottenham Hotspur | 0 | - | 1 | Chelsea |
| Arsenal | 0 | - | 2 | Liverpool |
| | | | |
| Football League (EFL) Cup Final | Football League (EFL) Cup Final | Football League (EFL) Cup Final | Football League (EFL) Cup Final | Football League (EFL) Cup Final |
| Wembley Stadium, Sunday 27th February 2022 | Wembley Stadium, Sunday 25th April 2022 | Wembley Stadium, Sunday 25th April 2022 | Wembley Stadium, Sunday 25th April 2022 | Wembley Stadium, Sunday 25th April 2022 |
| Chelsea | 0 | - | 0 | Liverpool (Pens 11-10) |
