5th November 2021
The seven Clubs Southampton FC scored Premier League Hat-Tricks against are
- Oldham Athletic (Matthew Le Tissier)
- Liverpool (Matthew Le Tissier)
- Norwich City (Matthew Le Tissier)
- Nottingham Forest (Matthew Le Tissier)
- Fulham (James Beattie)
- Aston Villa (Sadio Mané)
- Manchester City (Sadio Mané)

More trivia: Hat-tricks trivia · Southampton trivia · All trivia topics
Stats: Southampton stats · Premier League hat-tricks
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