Major League Soccer 2022 match schedule for MLS Eastern Conference and MLS Western Conference. View MLS fixtures from match day 1 to match day 33. MLS regular season began on February 26, 2022 and will conclude on October 9, 2022 with the MLS Cup Final being scheduled to occur on November 5, 2022. MLS 2022 is the 27th season of the top professional soccer league in US and Canada. There are 28 MLS clubs in season 2022.